we have the pleasure to invite you to the Particle Theory Seminar on Tuesday, May 30 at 12:15, which will be given by
Maciej Majka, Marcin Zagórski (IFT UJ)
„ Formation of gene expression patterns in biological systems “
“The development of multicellular organisms is a dynamic process in which cells divide, rearrange, and interpret molecular signals to adopt specific cell fates. This results in the emergence of gene expression patterns, that later on give raise to different body parts and organs. We still lack full understanding of how these patterns could form and remain stable during organism development. In this talk we address this question by considering reaction-diffusion model with two genes interacting via diffusible signaling molecules, controlling the size of their own source regions. By identifying the conservation law describing the number of particles reaching the front of the activated expression domain, we derive a range of analytical results. In particular, we observe the phase transition between patterns with expanding contact zone and patterns with contact zone of a well-defined size. Further, we provide exact conditions ensuring pattern stability. Finally, we classify two-gene regulatory motifs found in biological systems into classes resulting in different stability regimes.”
The seminar will be in a hybrid mode, local people are invited to meet in the seminar room D-2-02.
Piotr Korcyl, Jacek Wosiek, Michał Praszałowicz